Peer Reviewed Research

In-Clinic Measurements of Vascular Risk and Brain Activity

This study, published in 2022, explores two major health problems in cardiovascular disease and dementia and seeks to find links in the risk factors for both. The data for this study focused on a population of healthy patients whose routine clinical examinations were retrospectively analyzed for links between their vascular risk and brain activity. The results indicate a positive association between markers of cardiovascular and brain health. In particular, higher P300 amplitudes and shorter P300 latencies were shown in groups with healthier cardiovascular measures while groups with high blood pressure correlated with deficits in P300 metrics.

Event related potentials (ERP’s) after sports concussion; a 4 year study

This published study tracked a mixed group of Division 1 athletes throughout several competitive seasons. The study showed that concussed players experienced significant reaction time and/or P300 amplitude changes compared to pre-concussion baseline measurements. This data suggests significant P300 amplitude changes after concussion that are quantifiable and consistent. P300 measurements from this study showed that 38% of athletes who suffered a concussive event were cleared too early by standard return to play protocols.

Electrophysiological trajectories of concussion recovery: From acute to prolonged stages in late teenagers

This study, published in 2023, explores recovery trajectories from acute concussion to symptom recovery and the transition from acute concussion to prolonged phases. The study shows that prolonged concussion groups presented with significantly different spectral and coherence patterns as opposed to return to play and acute concussion groups. Meaning there are likely reliable QEEG markers that can distinguish acute vs. prologed concussion symtoms. 

P300 Evoked Response Potentials Patterns in Different Complex Concussion Phenotypes

This study, published in 2021 looks at different complex concussion phenotypes and assesses their relationship with EEG and ERP metrics. It was found that P300 ERPs can help identify neurophysiology associated with prolonged and compolex concussion cases. The study suggests that EEG/ERP metrics could potentially aid in diagnosis, prognosis, subtyping, and targeted phenotype management of complex concussions. 

White Papers

P300 Parameters Over the Lifespan

This article assesses the P300 data of 1,787 individuals in attempt to establish in-person P300 test-retest variances as validating age-related target ranges for P300 metrics. The data suggests that P300 metrics corroborate the age-related trends of published research done over the last several decades. Also, large between-person variance remain, leaving P300 best suited for within-person comparison. 

Measurements of EEG Alpha Peak Frequencies Over the Lifespan: Validating Target Ranges on an In-Clinic Platform

This white paper looks at EEG and P300 data from 2,025 individuals in attempt to validate testing methods used to acquire alpha frequency metrics. Peak individual alpha frequencies (IAF) extracted from an EEG exam can provide novel sources of information regarding brain function. This study showed that IAF is a stable trait, making it useful for within-person tracking. By following changes in IAF over time, deviations from normal CNS functioning, such as onset or progression of disease, can be monitored. 

Case Studies

Combat Veteran effectively treated with Stellate Ganglion block and Hyperbaric Oxygen Therapy

This case study focuses on a Vietnam combat veteran with a history of post traumatic stress disorder (PTSD) who was successfully treated with hyperbaric oxygen treatment (HBOT), and ultrasound guided stellate ganglion block. WAVi EEG testing was utilized prior to the intervention and was repeated in three months showing improvement in cognitive functioning. 

Post Viral Fatigue Syndrome effectively treated with Hyperbaric Oxygen Therapy

This study looks at the case of 27-year old patient who had been experiencing symptoms of brain fog and fatigue. After approximately 20 hours of hyperbaric oxygen treatment (HBOT), the patient experienced significant improvement in symptoms. This improvement in subjective symptoms was also objectively demonstrated by before and after WAVi EEG scans. These scans showed overall improvement in P300 metrics as well as spectrum analysis.